Canalicular transporters also involved in inherited forms of intrahepatic cholestasis such as the bile salt export pump (PFIC2, ABC11B) have been found phosphorylated by PKC when overexpressed in insect cells (Noe et al., 2001) and the floppase ABCB4 (PFIC3), known to transport PC in the opposite direction compared to ATP8B1, was shown to be stimulated by PKA- and PKC-dependent phosphorylation (Gautherot et al., 2014). Here, ATP8B1 is linked to intrahepatic cholestasis.