The data revealed that both early (0.26 ± 0.06 vs. 0.10 ± 0.01%, P < 0.05) and late apoptosis (0.21 ± 0.04 vs. 0.06 ± 0.01%, P < 0.05) were dramatically increased in RIG-I-overexpressing melanoma cells compared with control cells. Here, RIGI is linked to melanoma.