SERPINA3 and Alzheimer disease: Among the nine analyzed transcripts, as for the marked upregulation of SERPINA3 in both sCJD (average FC = 54) and AD at early stages of NFT pathology (average FC = 32.7) groups [22], a significant upregulation of SERPINB1 in affected patients (average FC = 5.2 for sCJD; average FC = 4.6 for AD) compared to controls was found.