MAPT and amyotrophic lateral sclerosis: Recently, it has been proposed that this mechanism also characterizes Amyloid-β (Aβ), tau, α-synuclein, SOD1, TDP-43, and huntingtin, involved in AD, PD, amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration, and Huntington’s disease, respectively.