CDH11 and cartilage disease: Cadherin-11 is a cell adhesion molecule expressed by hMSCs, and we recently reported that it is crucial for their commitment toward the adipogenic lineage.4 Other studies have also implicated cadherin-11 in hMSC differentiation.5,6 HMSCs have shown their potential for the treatment of type 2 diabetes, bone and cartilage disorders, among many others, all of which consider commitment toward the adipogenic lineage an undesired outcome.7-9 This is because adipogenic differentiation of hMSCs occurs at the expense of osteogenic and chondrogenic lineage specificity.