In bioinformatics analysis, we took the intersection of upregulated genes identified in TCGA-GBM dataset, TCGA-LGG dataset, and the GSE140746 microarray, four glioma-related candidate genes were thereupon obtained, namely AQP4, BIRCS, MAGT1, and MGP (Figure 1)). The gene discussed is AQP4; the disease is central nervous system cancer.