For instance, MiR-130b was highlighted as an oncogene in glioma via regulating the ERK/MAPK signaling pathway [27]; interference of angiopoietin-like protein 2 was found to repress glioma cell proliferation and invasion through blocking the ERK/MAPK signaling pathway [8]; and Cedrelone exhibited antitumor activity in temozolomide-resistant human glioma partially based on modulation of the ERK/MAPK signaling pathway [28]. Here, ANGPTL2 is linked to central nervous system cancer.