In addition, research into the treatment of ESCC has revealed a number of potential therapeutic targets such as orai1-mediated calcium signaling and PFKL (phosphate kinase, live type), however, further research is still needed (Zhu et al., 2014; Cui et al., 2018; Zheng et al., 2022). The gene discussed is ORAI1; the disease is esophageal squamous cell carcinoma.