SUGCT and infection: These changes are relatedto different colony phenotypes known as SCVs.58 Based on previous research, MPs such as Ga3+PPIX inducedthis phenotype by inhibiting respiration or inducing oxidative stress,which was indistinguishable from genetic SCVs.52 The SCV phenotype appears to be responsible for chronicand recurrent infections and is also highly resistant to antibiotics.59 We observed the presence of the SCV phenotypeduring 16–20 h of light-independent, constant cultivation ofbacteria with Ga3+MPIX (Figure S4A–C).