MAPT and Alzheimer disease: This is particularly interesting, as this fragment, along with the C-terminal portion of Coil 2B, have the largest separation between Alzheimer’s disease and control samples and have the highest correlation with disease-specific clinical markers such as markers of tau pathology, but have a lower correlation with the ELISA than NfL324, suggesting that this is a new isoform that may not be well identified by current ELISA assays.