There have been many studies on the relationship between any TNF-α/TNFR1/ANXA1 combination: absence of TNFR1 in intestinal inflammation enhances ANXA1 activity [22]; upregulation of ANXA1 inhibits maturation of human dendritic cells induced by TNF-α [23]; in preeclampsia, ANXA1 correlates positively with TNFR1 [24]. The gene discussed is TNF; the disease is preeclampsia.