PECAM1 and diabetes mellitus: The CD31 positive cells in wound tissues were identified by immunohistochemistry on days 7, 14 and 21, respectively after burns, and we found that diabetes (STZ/VEH) significantly reduced the generation of CD31 positive cells compared to the CTL/VEH group; treatment with either BA-TOP or BA-IP showed little effect, while this effect was completely reversed in the BA-IP/TOP group (Figure 6a, b).