SLC2A4 and diabetes mellitus: We also evaluated the potential effect of BA on fibroblast cells isolated from the skin of treated mice and found that BA treatment completely reversed diabetes (STZ)-mediated GLUT4 suppression (Figure S3a, see online supplementary material), partly reversed diabetes-induced epigenetic changes on the GLUT4 promoter (Figure S3b), and completely reversed diabetes-mediated glucose uptake (Figure S3c).