VEGFA and Infertility: VEGF is a factor in the development and homeostasis of germ cells (in seminal epithelium), Leydig and Sertoli cells [6, 40] and based on the results of Agrawal et al. (2002) abnormal levels of VEGF may have a destabilizing effect on the testicular cells and be a key factor in the pathogenesis of infertility [7].