The analysis of TGF-β1 mRNA expression in mouse testis after administration of ALS showed significantly lower levels in MTEP + NS-398 and IMI + NS-398 groups (p < 0.05, p < 0.05; respectively) and they were 3.018-fold and 5.88-fold lower versus the control group [F(5,36) = 2.827; p = 0.0297] (Figs. 1B, 2). The gene discussed is TGFB1; the disease is amyotrophic lateral sclerosis.