Therefore, the objective of this study was to assess the effect of ALS and LPS (lipopolysaccharide E. coli) on the expression level of growth factors: IGF-2, TGF-β1, NGF, KGF and on protein synthesis of VEGF-A, IGF-IRβ, EGFR (epidermal growth factor) and klotho in the testis of the adult mice. This evidence concerns the gene TGFB1 and amyotrophic lateral sclerosis.