A higher LDL/HDL ratio was found in MDD patients along with a reduction in omega-3 fatty acids levels [47,60] and a positive correlation between the Montgomery-Åsberg Depression Rating Scale (MADRS) score and serum levels of LDL, triglycerides, cholesterol, free cholesterol, phospholipids and apolipoprotein B before treatment [50]. This evidence concerns the gene APOB and major depressive disorder.