Anti-TIF-1-g and anti-nuclear matrix protein-2 antibodies suggest a greater risk of cancer, while Jo-1 is an MSA that recognizes histidyl-RNA-synthetase and belongs to the group of antibodies against aminoacyl-tRNA synthetases [15] and is an immunological marker for DM that has an increased diagnostic specificity but is only found in 30% of patients [34]. The gene discussed is TRIM24; the disease is cancer.