A separate biologically active hormone from NT-proBNP, BNP has a shorter half-life and can be affected by use of the angiotensin receptor-neprilysin inhibitor (ARNI) class of HF therapeutics.58 As such, high-sensitivity troponin and BNP concentrations are not interchangeable biomarkers for the previously described staging systems. This evidence concerns the gene NPPB and hydrops fetalis.