TTR and hydrops fetalis: Men and women are equally affected.41 On the other hand, prototypical hATTR-CM usually has a later onset than TTR-FAP, with symptoms occurring mostly after age 60.42 It manifests as unexplained left ventricular hypertrophy leading to restrictive cardiomyopathy, HF, atrial fibrillation, and conduction abnormalities.43,44,45