Regulation of the NF-κB pathway by Honokiol may reduce ROS levels and endothelial cell apoptosis in high-glucose-stimulated oxidative stress and streptozocin- (STZ-) stimulated diabetes [33], inflammatory response, apoptosis of human umbilical vein endothelial cells [34], and even the proliferation and migration of rat aortic smooth muscle cells [35]. Here, NFKB1 is linked to diabetes mellitus.