In addition, pretreatment with Honokiol was also observed to significantly reduce infarct size and the levels of proinflammatory cytokines (TNF-α, NF-κB, and IL-6), oxidative stress indicators (myeloperoxidase, superoxide dismutase, catalase, malondialdehyde), and myocardial injury indicators (cTnT and CK-MB) in MI/RI [15]. The gene discussed is NFKB1; the disease is myocardial infarction.