TIMP2 and colorectal carcinoma: Since TDG binds to DNMT3A and promotes its degradation, and DNMT3A can bind to the TIMP2 promoter to regulate its methylation and TIMP2 transcription, does TDG also change the methylation of the TIMP2 promoter and inhibit CRC metastasis through the TDG-DNMT3A-TIMP2 pathway?