PARIS not only interacts with 160-kDa Myb-binding protein 1α, a suppressor in rRNA transcriptional and rRNA editing processes, but also communicates with the components of RNA polymerase I. Since these studies have partially verified the close connection between PD and ribosomal dysfunction, development of drugs in relieving nucleolar stress and restoring ribosomal function might bring about breakthroughs in treating patients with PD. The gene discussed is ZNF746; the disease is Parkinson disease.