SAV1 and neoplasm: The HIPPO pathway is an evolutionally conserved signalling pathway that plays a crucial role in mediating organ size control, tissue regeneration and stem cell self-renewal.15 The core Hippo components include mammalian sterile 20-like 1/2 (MST1/2), Large tumour suppressor homologue 1/2 (LATS1/2), Salvador (SAV1), MOB kinase activator 1A/B (MOB1 A/B), and Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ).16 Recent studies have highlighted the vital role of the Hippo pathway in the occurrence and development of a variety of tumours.