YAP can be bound by ABL1 in the cell nucleus and then can be phosphorylated on tyrosine 357, which augments the stability of P73, activates the proapoptotic gene and ultimately promotes the apoptosis of MM cells.25 Therefore, we further examined the levels of P73-target genes (P21, PUMA and BAX) and P-YAP (Y357) through western blot analysis. This evidence concerns the gene BAX and Miyoshi myopathy.