It accelerates the proliferation, invasion and metastasis capacity of pancreatic ductal adenocarcinoma cells by activating the Wnt signalling pathway.11 In addition, ALKBH5 increases the level of NANOG mRNA in breast cancer cells and promotes the enrichment of breast cancer stem cells.12 What's more, ALKBH5 promotes tumorigenesis in acute myeloid leukemia (AML) via facilitating leukaemia stem/initiating cells (LSCs/LICs) 13, 14 However, the role of ALKBH5 in MM has rarely been reported. This evidence concerns the gene NANOG and acute myeloid leukemia.