Knocking out the SAV1 gene induced hepatocellular carcinoma in mice via the activation of YAP/TAZ,17 and high YAP/TAZ levels were closely associated with the poor prognosis of breast cancer, gastrointestinal cancer, and non-small cell lung cancer.18-20 Recently, it was found that increased YAP significantly promotes the apoptosis of myeloma cells.21 However, the specific upstream regulatory mechanisms of the Hippo pathway remain unclear. Here, SAV1 is linked to plasma cell myeloma.