In recent years, emerging evidence has revealed that m6A methylation is involved in cancer stem cell generation and maintenance, governing cancer progression and therapeutic resistance, which highlight the potential of m6A methylation as a novel target for cancer therapeutics.47 ALKBH5 overexpression increased the percentage of breast cancer stem cell via inducing m6A -demethylation of NANOG mRNA. This evidence concerns the gene NANOG and breast cancer.