Firstly, the m6A level in the RNA samples taken from ALKBH5- MM cells, control MM cells and bone marrow-derived CD138+ cells from healthy volunteers (normal controls, NCs) were detected using an EpiQuick m6A RNA methylation quantification kit and found that the m6A methylation levels in the NCs and ALKBH5- myeloma cells were notably higher than those in the control MM cells (Figure 4A). The gene discussed is SDC1; the disease is plasma cell myeloma.