Blockage of Yap resulted in a slow progression from G1 into S phase and down-regulated the expression of Ccnd1, Ccnd3 and Cdk4, indicating an importance of Yap in governing G1/S phase transition, which was further highlighted by these evidences that sustained activation of Yap accelerated the transition of podocytes and cardiomyocytes to enter into S phase, whereas depletion of Yap in KYSE170 cells and malignant mesothelioma cells caused cell cycle arrest at G1 phase 30-33. The gene discussed is CCND3; the disease is malignant mesothelioma.