Whilst all the recipients in both groups died due to the BRC/ABL1 induced B-ALL, the mice transplanted with Roraloxp/loxp BM died significantly faster (p=0.0174), with a median survival time of 46 days post BMT (BM transplant) verses 62 days for the WT group (Figure 6A). This evidence concerns the gene ABL1 and precursor B-cell acute lymphoblastic leukemia.