Our analysis results suggested that the DNA methylation levels of all of these CpG sites were significantly higher in ccRCC compared with AN tissue (Fig. 4A and B), and the DNA methylation levels of nine of these 10 CpG sites were significantly negatively correlated with the APCDD1L-AS1 expression level (Fig. 4C). The gene discussed is APCDD1L; the disease is nonpapillary renal cell carcinoma.