First, we analyzed APCDD1L-AS1 expression in ccRCC and AN tissue using the transcriptome sequencing data of TCGA-KIRC, and the paired and unpaired t test results indicated that APCDD1L-AS1 expression was significantly reduced in ccRCC compared with AN tissue (Fig. 1A). The gene discussed is APCDD1L; the disease is nonpapillary renal cell carcinoma.