For example, ZNF582-AS1 restrained the growth and metastasis of ccRCC by regulating the N(6)-methyladenosine modification of MT-RNR1 15, and PVT1 promoted the tumorigenesis and metastasis of ccRCC by stabilizing HIF2α 16. The gene discussed is MT-RNR1; the disease is nonpapillary renal cell carcinoma.