VHL and renal cell carcinoma: Our results identified that APCDD1L-AS1 expression was significantly decreased in these RCC cell lines compared with HK2 cell line, and the expression of APCDD1L-AS1 was also remarkably reduced in 786-O and RCC4 cell lines (with a VHL mutant) compared with Caki-1 cell line (VHL wild-type) (Fig. 1F).