The third-generation of CAR-T cells with an scFv region of anti-EGFR antibodies showed antitumor and cytotoxic effects in TNBC cell cultures (HS578T, MDA-MB-231, MDA-MB-468) and TNBC cell lines derived xenograft mouse models through mechanisms of enhancing cytokine release and tumor lysis62. The gene discussed is EGFR; the disease is neoplasm.