PTK2 and hepatocellular carcinoma: In a study on endometrial cancer, miR-148a expression was decreased in CAFs, which contributed to tumor cell motility.26 It is also determined that over-expression of miR-148a in CAFs significantly impaired the invasive and migrative ability of oral carcinoma.27 Hsin-Jung Wu et al have shown that miR-148a derived from CAFs decreased mammary tumor functions and metastasis through FAK signaling.28 Our data have indicated that low miR-148a-3p expression in CAFs has a positive correlation with that in exosomes, which promoted the proliferation and invasion of co-cultured HCC cells.