According to the results, when CRC cells with downregulated expression of MGP were co-cultured with antigen-specific CD8+ T cells, the expression of common markers of CD8+ T cell exhaustion (for example, LAG3, PD1, TIGIT, and TIM3) was noticeably decreased (Figure 4A-4D, Figure 4I-4L). The gene discussed is HAVCR2; the disease is colorectal carcinoma.