IL6 and dermatitis: We have shown that 1) loss of Rev-erbα in mice exacerbates P. acnes-induced skin inflammation, a phenotype similar to that of Bmal1-/- mice, 2) Rev-erbα silencing attenuates the inhibitory effects of Bmal1 overexpression on the expression of the pro-inflammatory factors Cxcl1, IL-1α and IL-6, and 3) Bmal1 knockdown fails to alter the expression of Cxcl1, IL-1α and IL-6 in Rev-erbα-silenced cells.