AKT1 and malignant colon neoplasm: 13. Moreover, our former studies demonstrated that anti-proliferative activity and apoptosis were strictly dependent on SIRT6 activation through inhibiting AKT by BKM120 in colon cancer cells 15. Ipatasertib as a novel AKT inhibitor causes the transcription factor FoxO3a and NF-κB directly PUMA-dependent apoptosis 16. Our group also found that the anti-tumor efficiency of the small molecular AKT inhibitor SC66 through AKT/GSK-3β/Bax pathway 17.