Collectively, all of these data demonstrated that mutant p53 transcriptionally inhibits PHLPP2 and activates AKT/4EBP1/eIF4E pathway to up-regulates PD-L1 expression, subsequently suppresses the immune response and executes its Gain-of-Function in tumor growth (Figure 8B). The gene discussed is EIF4EBP1; the disease is neoplasm.