In this study, we identified USP7 as a bona fide DUB for IKZF1, which is supported by the following evidence: USP7 interacts and co-localizes with IKZF1 in MM cells; USP7 can remove the ubiquitin from IKZF1; inhibition of USP7 induces degradation of IKZF1 while overexpression of USP7 stabilizes IKZF1. The gene discussed is IKZF1; the disease is Miyoshi myopathy.