As shown in Fig. 6, co-treatment of P5091 with olaparib synergistically inhibited the proliferation of NCI-H929 (Fig. 6A), MM1.S (Fig. 6B), and primary CD138+ MM cells (Fig. 6C-D), but not normal BM mononuclear cells (Fig. 6E). The gene discussed is SDC1; the disease is Miyoshi myopathy.