More importantly, by using the MM xenograft model, we demonstrated that the combination of lenalidomide with olaparib (Fig. S6E) could significantly reduce tumor size (Fig. S6F-H), inhibit cell proliferation (S6J, K, Ki67 staining) compared with using either drug alone, but has no significant effect on the body weight (Fig. S6I). Here, MKI67 is linked to Miyoshi myopathy.