Several lines of evidence supported this notion: knockdown or inducing degradation of IKZF1 results in the increase of γH2AX foci formation in myeloma cell lines; deletion of IKZF1 also causes the increase of γH2AX foci formation in MEF cells; integrated reporter assays showed that IKZF1 is involved in HR. This evidence concerns the gene IKZF1 and plasma cell myeloma.