Indeed, exogenous Myc-IKZF1 in HEK293T cells (Fig. 3B) and endogenous IKZF1 in MM cell lines (Fig. 3C) could pull down USP7, and reciprocal IP of exogenous USP7 effectively pulled down IKZF1 (Fig. 3B). This evidence concerns the gene IKZF1 and Miyoshi myopathy.