For example, immunomodulatory drugs (IMiDs), such as lenalidomide, can induce the degradation of IKZF1 by activating E3 ubiquitin ligase cereblon (CRBN), which in turn results in the downregulation of c-Myc and IRF4, and inhibits the proliferation of MM cells 20, 21, 27. Here, IKZF1 is linked to Miyoshi myopathy.