CTSL mutation analysis in different tumors showed the highest mutation rate in UCEC (Uterine Corpus Endometrial Carcinoma) (20/531=3.77%), followed by DLBC (Lymphoid Neoplasm Diffuse Large B-cell Lymphoma) (1/37=2.70%), and HNSC (Head and Neck squamous cell carcinoma) showed the lowest (1/509=0.19%) mutation rate (Figure 3D). This evidence concerns the gene CTSL and uterine corpus endometrial carcinoma.