PBX3 and neoplasm: Therefore, to resolve the underlying mechanism by which ATRAP promotes breast cancer progression, we used the BioGRID database (https://thebiogrid.org/) to explore potential ATRAP interaction partners, which revealed a variety of candidate proteins, among which we selected PBX3 for closer scrutiny based on its reported function in promoting tumor migration and invasion 30, 31 (Figure 4A and Table S4).