Besides, we tested the expression of CLDN10 in five ccRCC cell lines (786-O, 769-P, OSRC2, A498 and Caki-1) and two control cell lines (HK2 and HEK293), and found that CLDN10 expression was generally reduced in these ccRCC cells compared to the HK2 cells (Fig. 1D). The gene discussed is CLDN10; the disease is nonpapillary renal cell carcinoma.