The effect of changes in CLDN10 expression on the apoptosis of ccRCC cells was detected by the immunofluorescence TUNEL method and flow cytometry, the effect of changes in CLDN10 expression on the growth of ccRCC cells was detected by the immunofluorescence EdU method and clone formation experiment, and the effect of changes in CLDN10 expression on the metastatic ability of ccRCC cells was detected by cell migration and invasion experiments. Here, CLDN10 is linked to nonpapillary renal cell carcinoma.