CLDN10 and nonpapillary renal cell carcinoma: All in all, the preset study has clarified the role of CLDN10 as a tumor suppressor gene in ccRCC, and for the first time illustrates the mechanism by which CLDN10 suppresses the growth and metastasis of ccRCC, which will provide important theoretical support for the exploitation of a novel therapeutic target to inhibit the progression of ccRCC.