For instance, SIRT3 expression was an independent predictor of esophageal cancer treatment, and the higher the expression, the worse the prognosis 22; SIRT3 promoted survival and protected cells from damage by regulating apoptotic factors in fibrosarcoma, cervical cancer, bladder cancer and oral squamous cell carcinoma 23-25, overexpression of SIRT3 restrained the growth of kidney tumor cells and enhanced mitochondrial biogenesis 26. The gene discussed is SIRT3; the disease is fibrosarcoma.