Besides, immunohistochemistry was used to detect the expression of EdU, TUNEL and Cleaved-Caspase 3 in kidney tumors and to detect the expression of E-cadherin and N-cadherin in lung metastases, results showed that the expression of EdU and N-cadherin were significantly decreased and the expression of TUNEL, Cleaved-Caspase 3 and E-cadherin were significantly increased in the kidney tumors and lung metastases of CLDN10 overexpression group (Fig. 8D-G). This evidence concerns the gene CASP3 and kidney neoplasm.