Meanwhile, the evidence is inconclusive regarding the relationship between GR-α overexpression and severe asthma.39 Alternatively, the reduction of HDAC activity is linked to phosphorylation by a phosphoinositide 3-kinase that is activated by oxidative stress.40,41 GC-resistant asthma might have a genetic predisposition, and there is speculation that it’s linked to certain genetic variants, in particular, glucocorticoid-induced transcript 1 gene (GLCCI1).42,43. The gene discussed is GLCCI1; the disease is asthma.