Four weeks after the transplantation, the human hematopoiesis reconstitution assessed by flow cytometry in BM was found tenfold lower, when mice were injected with CD34+ cells exposed to T-ALL or B-ALL EVs, compared with mice transplanted with CD34+ cells either untreated or exposed to NSG EVs (Fig. S11B). Here, CD34 is linked to acute lymphoblastic leukemia.