ESR1 and breast cancer: DA and PMD showed positive genetic correlations with overall breast cancer (DA: rg = 0.24, p = 1.11 × 10−4; PMD: rg = 0.29, p = 1.90 × 10−9), ER-positive (DA: rg = 0.21, p = 2.59 × 10−4; PMD: rg = 0.26, p = 4.71 × 10−8), and ER-negative breast cancer (DA: rg = 0.26, p = 1.04 × 10−3; PMD: rg = 0.27, p = 5.95 × 10−5).