BRCA1 and central nervous system cancer: We labeled FEN1, BRCA1 and RAD51 in glioma mouse samples and observed decreased BRCA1 and RAD51 expression upon treatment with the specific FEN1 inhibitor sc13 [41], confirming the regulatory role of FEN1 on BRCA1 and RAD51 in glioma cells (Fig. 3a and b).