As CRP2 is highly and preferentially expressed in VSMCs, protects against arterial injury-induced intimal hyperplasia [20], and that both CRP2 and SM22α were identified as top differentially expressed genes in IAA SMC clusters [8], we initially hypothesized CRP2 may play a similar role as SM22α in reducing AAA formation. The gene discussed is CSRP2; the disease is triple-A syndrome.