G6PD and neoplasm: Moreover, a study manifested that synthesized flavor-derived GL-V9 could reduce glucose-6-phosphate dehydrogenase (G6PD) and increase phospho-acetyl-CoA carboxylase (p-ACC) by activating the activity and expression level of AMPK, and finally activate anoikis to inhibit the tumor metastasis of MDA-MB-231 TNBC cell line and TNBC xenograft nude mice [271].