Aquaporin1 (AQP1), a water transport membrane protein related to tumor development and progression [220, 221], as a carcinogenic biomarker of a variety of cancers [222–224], could inhibit RIPK1/MLKL/RIPK3-mediated necroptosis and RIPK1/caspase-8/caspase-3-mediated apoptosis by binding to d324 site of ripk1, driving the progression of TNBC [225]. Here, CASP3 is linked to neoplasm.