It would be speculated that TIGIT, KLRG1 and its ligands PVR, E-cadherin and N-cadherin are involved in the immune response of CD56brightNK cells in HPV16(+) CIN, affecting the immune status of patients in different clinical stages to a certain extent, and promoting the progression of CIN. The gene discussed is CDH2; the disease is cervical squamous intraepithelial neoplasia.