In order to identify the inhibitory receptors that affect the function of CD56brightNK cells in the progression of HPV16(+) CIN, we screened some of candidates recrptor: TIGIT, KLRG1, Siglec-7, LAIR-1, CD300a and NKG2A, and all data were shown in Table 1. The gene discussed is LAIR1; the disease is cervical squamous intraepithelial neoplasia.