However, the expression levels of HPV16(+) CIN I group and CIN II–III group were significantly higher than that of the control group (P < 0.0001), and the expression of E-Cadherin and N-Cadherin increased with the increasing CIN grade (Fig. 4A b, c, Bb, c). This evidence concerns the gene CDH1 and cervical squamous intraepithelial neoplasia.