The stimulation of CB2 signaling by AM1241 diminished the development of myocardial fibrosis during the post-myocardial infarction phase via enhancing the translocation of the fibrogenesis-associated transcription factor Nrf2 to the nucleus and blocking the TGF-β1/Smad3 pathway82. Here, TGFB1 is linked to Myocardial fibrosis.