Carriage of the minor allele (AD risk odds ratio (OR) = 0.92) was associated with significant reduction in normalized protein expression (NPX) of PILRB and PILRA compared to individuals homozygous for the major allele (FDR-adjusted p-values = 2.2 × 10–33 and 2.3 × 10–17, respectively), while the overall level of NPX increased with age among all genotypes. This evidence concerns the gene PILRB and Alzheimer disease.