APOE and Cognitive impairment: DG-rich diets fed to diabetic APOE-knockout mice had reduced atherosclerosis and lower plasma cholesterol than mice fed TG-rich or western diets32,33; however, non-targeted metabolomics studies have shown elevated levels of DGs and MGs in AD and mild cognitive impairment (MCI) patient brains and blood compared to cognitively intact individuals34,35.