Levels of pro-inflammatory cytokines, including IL-6 and IL-17A, critical cytokines for Th17 cell differentiation and function18, were higher in the combined ICI arthritis group than in the PD-1 inhibitor arthritis group, although the differences were not statistically significant (IL-6; PD-1 inhibitor arthritis vs. combined ICI arthritis; 2234 ± 1,438 vs. 2928 ± 1684 pg/mL; P = 0.38) (IL-17A: PD-1 inhibitor arthritis vs. combination therapy arthritis; 14.5 ± 16.8 vs. 31.2 ± 20.0 pg/mL; P = 0.25). The gene discussed is IL17A; the disease is Arthritis.