Likewise, IFNγ+ CD8+ T cells and Tc1 cells were contracted after treatment of arthritis-irAE; however, the differences did not reach statistical significance (% of IFNγ+ CD8+ T cells; before vs. after arthritis treatment; 32.9 ± 11.5 vs. 26.7 ± 15.6; P = 0.07) (% of Tc1 cells; before vs. after arthritis treatment; 32.5 ± 11.6 vs. 26.4 ± 15.7; P = 0.07) (Fig. 6c). This evidence concerns the gene CD8A and arthritic joint disease.