Similar to rheumatoid arthritis, in arthritis-irAE, SF T cells highly expressed CXCR3 and CXCR6, and their matching ligands, CXCL9/10/11, and CXCL16 were mainly produced by myeloid cells (Fig. 4c; Supplementary Figs. 3c, 4). This evidence concerns the gene CXCR6 and arthritic joint disease.