IL-17+ CD4+ T cells in SF were significantly enriched in the combined ICI arthritis group compared with the PD-1 inhibitor arthritis group (% within CD4+ T cells; PD-1 inhibitor arthritis vs. combined ICI arthritis; 1.52 ± 1.49 vs. 3.42 ± 0.89; P = 0.03). This evidence concerns the gene CD4 and arthritic joint disease.