Cytokine profiles in SF CD8+ cells were similar, including enrichment of IL-17–producing CD8+ T cells and IFNγ+ IL-17+ CD8+ T (t-Tc17) cells; however, the difference did not reach statistical significance (% of IL-17+ CD8+ T cells; PD-1 inhibitor arthritis vs. combined ICI arthritis; 0.60 ± 0.61 vs. 1.37 ± 0.82; P = 0.11) (% of t-Tc17 cells; PD-1 inhibitor arthritis vs. combined ICI arthritis; 0.35 ± 0.46 vs. 0.97 ± 0.66; P = 0.10) (Fig. 5b; Supplementary Fig. 6b). This evidence concerns the gene PDCD1 and arthritic joint disease.