Depletion of microglia significantly reduced the number of tau inclusions in AT8+ neurons in both contralateral and ipsilateral cortex of PS19 mice inoculated with PSP brain extract, consistent with the notion that microglia promote tau seeding and spreading in mouse tauopathy models17 (Supplementary Fig. 4e, f). The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.