Elevated neuron cell death and impaired neuronal activity in mouse model overexpressing miR-203 in the hippocampus were further displayed by TUNEL assay and PSD95 immunoblot, in agreement with the results from Swarup et al., who suggested that miR-203 was a hub regulatory miRNA in regulating apoptosis and was associated with the disease progression of frontotemporal dementia [13]. This evidence concerns the gene DLG4 and frontotemporal dementia.