Although the detailed functions of 14-3-3 were behind the mist, neuroprotective roles were ascribed to 14-3-3 in various pathological conditions, for instance, prevent phosphorylated tau aggregation in neurofibrillary tangles in Alzheimer disease and prevent α-synuclein aggregation in Parkonson’s disease [23]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.