According to literatures, VEGF stimulates the expression level of the PI3K-Akt and MAPK-ERK proteins in the cerebral cortex of rats through phosphate Akt and activate MAPK-regulated ERK pathways, thus reducing the lesion volume of cerebral infarction and promoting angiogenesis in rats with cerebral infarction [44]. Here, PIK3CA is linked to brain infarction.