SIX4 and non-small cell lung carcinoma: For instance, miRNA-30 serves as an important regulator in NSCLC [8]; miRNA-621 suppresses the development of NSCLC through regulating SIX4 [9]; serum miRNA-365 targets TTF-1 to serve as a prognostic marker for NSCLC [10]; and overexpressed miR-21 is associated with clinicopathological features and poor prognosis of NSCLC patients [11].