Additionally, spindle-shaped cells were clearly reduced due to the downregulation of USP48 (Fig. 5G); the protein levels of ZO-1 and E-cadherin were enhanced while those of N-cadherin and Vimentin were attenuated after the silencing of USP48 in NSCLC cells (Fig. 5H). The gene discussed is TJP1; the disease is non-small cell lung carcinoma.