USP48 and non-small cell lung carcinoma: Subsequently, it was unearthed by the results of RNA pulldown assays that miR-489-3p was highly enriched in the complex pulled down by Bio-USP48 3’UTR-Wt instead of Bio-USP48 3′ UTR-Mut (Fig. 4D), indicating that miR-489-3p binds to USP48 in NSCLC cells.