However, following stratification of the CAIRO2 cohort, using the IHC-classifier for CMS that allows subtype classification of the epithelial (tumor cell) compartment, serum ADAM12 levels were found to be similar between CMS2/3 (n = 75) and CMS4 (n = 71) tumors (Fig. 4B; CMS1 are MSI tumors and excluded from analysis due to low numbers (n = 3)). This evidence concerns the gene ADAM12 and neoplasm.