A WGCNA approach with GBM RNA-Seq data was performed to find intersecting genes, and survival analysis was used to determine the significant key gene, FUBP3. We speculated that FUBP3 could accelerate the death of glioblastoma cells and increase the survival rate of patients by activating immune cells (CD4+ T cells, CD8+ T cells, and CD68+ macrophages). Here, CD8A is linked to glioblastoma.