Notably, IL-15 mDCs showed very good stimulatory capacity for autologous CIK cells, a higher proportion of CD44+, IFN-γ+, granzyme B+, and NKG2D in CIK cells, and a higher cytotoxicity of CIK cells against cancer cell lines and patient autologous primary myeloma cells. Here, GZMB is linked to plasma cell myeloma.