These results indicate that DCs generated with IL-15, especially those in the IL-15 mDCs (6 days) group, can robustly enhance the cytotoxicity and function of specific anti-cancer T cells, CIK cells, and NK cells, as indicated by the numbers of IFN-γ spots and levels of CD107a expression against ARH77, IM9, and K562 target cells. This evidence concerns the gene IL15 and cancer.