Furthermore, when scoring breast tumor tissues (GSE789588, n = 424) for the above signatures, divided or not based on inferred premenopausal status (<49 years old), a substantial fraction of obese cancer patients showed lower Akt activation scores (Fig 1B upper panel) (p<0.05), in comparison to normal-weight or overweight individuals, in contrast to what was observed in normal breast epithelium. This evidence concerns the gene AKT1 and breast neoplasm.