AKT1 and breast carcinoma: For example, by altering relevant oncogenic pathways such as the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling, which is activated by insulin, Insulin-like Growth Factor 1 (IGF-1), estrogens, progesterone, leptin, among others, which increases the risk of breast cancer development [4–17].