All animals exhibited marked deviation from baseline hematological and serum analyte values compared with baseline (day of challenge), including lymphocytopenia, thrombocytopenia, monocytopenia, neutrophilia, and elevated markers of hepatic/pancreatic injury (e.g., alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase [ALP], gamma-glutamyltransferase [GGT], serum amylase) and acute systemic inflammation (C-reactive protein [CRP]; Supplemental Table 1 and Supplemental Figure 1). The gene discussed is CRP; the disease is Thrombocytopenia.