In conclusion, circNOLC1 is increased during the progression of renal cell carcinoma; CircEHD2 inhibition reduces the resistance of RCC to SU; miR-4731-5p directly targets the circEHD2 and ABCF2 to arrest the establishment of renal cell carcinoma, and ABCF2 reverses the inhibitor effect of circEHD2 on SU resistance of RCC. The gene discussed is ABCF2; the disease is hereditary clear cell renal cell carcinoma.