The study aimed to determine circEHD2 expression in SU-resistant RCC tissues and cell lines, to understand the effect of circEHD2 inhibition on SU-resistance to RCC, to determine whether circEHD2 and ABCF2 are targets of miR-4731-5p in the inhibition of RCC, and to understand the effect of ABCF2 on circEHD2 in SU-resistance to RCC. This evidence concerns the gene ABCF2 and renal cell carcinoma.